Impact of symptom-to-reperfusion-time on transmural infarct extent and left ventricular strain in patients with ST-segment elevation myocardial infarction: a 3D view on the wavefront phenomenon
Authors' conclusion
In STEMI patients, time-to-reperfusion was significantly associated with smaller transmural extent of infarction and better LV circumferential and radial strain.
Study context
- Population
- STEMI patients with successful primary PCI
- Participants
- 108 patients
- Exposure
- Shorter vs longer symptom-to-reperfusion time
- Shortern = 54
- Longern = 54reference
- Outcome
- Cardiovascular magnetic resonance (CMR) transmural infarct extent and global LV strain
- Follow-up
- 2-7 days after PPCI and 1 month
Main finding
As reported in the abstract
- Mean transmural extent score at follow-up lower with shorter time
- P < 0.01
- Maximum transmural extent score smaller with shorter time (baseline and follow-up)
- P = 0.03
- More favourable global left ventricular (LV) circumferential strain with shorter time, baseline
- P = 0.049
- More favourable global LV circumferential strain with shorter time, follow-up
- P = 0.01
- More favourable LV radial strain with shorter time, baseline
- P = 0.047
- More favourable LV radial strain with shorter time, follow-up
- P < 0.01
- LV longitudinal strain comparable at baseline and follow-up
- P > 0.05
Observational data: associations, not effects.
Further findings
Baseline LV circumferential strain as independent predictor of mean transmural extent score at follow-up (multivariable regression)
- β
- 1.89
- P
- P < 0.001
Original publication
Impact of symptom-to-reperfusion-time on transmural infarct extent and left ventricular strain in patients with ST-segment elevation myocardial infarction: a 3D view on the wavefront phenomenon. Eur Heart J Cardiovasc Imaging. Published 9 October 2023. doi:10.
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