Acute cardiac care & resuscitationCohort study
Combined short- and mid-latency SSEP amplitudes for early prediction of favorable neurological recovery after cardiac arrest
- retrospective cohort study
Authors' conclusion
Quantitative assessment of the P25-N30 amplitude within 24 h after cardiac arrest was associated with favorable neurological outcome and may contribute to early multimodal prognostication.
Study context
- Population
- Comatose adult cardiac arrest patients treated with targeted temperature management between 2009 and 2023 who underwent SSEP recording within 24 h after return of spontaneous circulation (ROSC)29 (40%) achieved favorable neurological outcome
- Participants
- 73 patients
- Exposure
- P25-N30 amplitude vs N20-P25 amplitude
Main finding
As reported in the abstract
Cortical SSEP amplitudes by outcome
- Cortical SSEP amplitudes were consistently higher in patients with favorable outcomes
Observational data: associations, not effects.
Further findings
| Outcome | P25-N30 amplitude | N20-P25 amplitude | P value |
|---|---|---|---|
| Discrimination of favorable neurological outcome · 6 months · comparable performance | P = 0.417 | ||
| AUC | 0.943 (95% CI 0.862-0.984) | 0.922 (95% CI 0.836-0.972) | |
| sensitivity | 100% (95% CI 88.1-100%) | Not reported in the abstract | |
| specificity | 84.1% (95% CI 69.9-93.4%) | Not reported in the abstract |
Addition of non-SSEP predictors
- The addition of non-SSEP predictors did not significantly improve overall discrimination
Original publication
Combined short- and mid-latency SSEP amplitudes for early prediction of favorable neurological recovery after cardiac arrest. Resuscitation. Published 30 April 2026. doi:10.1016/j.resuscitation.2026.111118
Summarised from the published abstract; every number is checked against it