Valvular & structural heart disease
Comparative 30-day echocardiographic outcomes of Myval vs. Sapien and Evolut transcatheter heart valve (THVs): insights from LANDMARK trial
Authors' conclusion
The Myval THV series demonstrates short-term haemodynamic performance comparable to Evolut THV series and superior to Sapien THV series. Including intermediate sizes minimizes oversizing, underscoring its potential as an alternative for TAVI patients. Long-term follow-up is necessary to confirm these findings.
Study context
- Population
- Patients with aortic stenosis (AS) undergoing transcatheter heart valve (THV) implantation384 Myval THV series vs 384 Sapien and Evolut THV series
- Comparison
- Myval THV series vs Sapien and Evolut THV series
- Myval THV seriesn = 384
Methodological detailssub-study
- Sub-study
Primary result
As reported in the abstract
Myval THV series
85.9%
Sapien THV series
77.8
Evolut THV series
85.4%
Myval THV series vs Sapien THV series: PMyval-Sapien = 0.03 · Myval THV series vs Evolut THV series: PMyval-Evolut = 0.98
Further findings
Moderate prosthesis-patient mismatch (PPM) · 30-day — Myval THV series vs Sapien THV series · less frequent with Myval
PMyval-Sapien = 0.0024
Severe PPM · 30-day — Myval THV series vs Sapien THV series · no significant differences
PMyval-Sapien = 0.394
≥ moderate paravalvular leak (PVL) · 30-day — Myval THV series vs Sapien THV series
PMyval-Sapien = 0.3769
| Outcome | P value |
|---|---|
| Moderate prosthesis-patient mismatch (PPM) · 30-dayMyval THV series vs Evolut THV series · higher with Myval | PMyval-Evolut = 0.0396 |
| Severe PPM · 30-dayMyval THV series vs Evolut THV series · no significant differences | PMyval-Evolut = 0.2438 |
| ≥ moderate paravalvular leak (PVL) · 30-dayMyval THV series vs Evolut THV series · lower with Myval | PMyval-Evolut = 0.0336 |
- Oversizing · Myval THV series vs Evolut THV series · minimal oversizing with Myval
- P < 0.0001
Peak aortic flow velocity, pressure gradients, effective orifice area (EOA), Doppler velocity index (DVI), cardiac indices, left ventricular ejection fraction · 30-day
- Significant improvements across all groups, except for unchanged left ventricular ejection fraction
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →