Arrhythmias & electrophysiology
Comparative clinical profiles and outcomes of prior vs. concurrently diagnosed atrial fibrillation in acute ischaemic stroke: the implication of diagnosis timing
Main finding · Net clinical outcomeResult — go to the resultAdjusted hazard ratio 0.776 95% CI 0.611–0.986Authors' conclusion
Prior AF and AFDCS have distinctive clinical profiles supporting AF is a disease of continuum according to its diagnostic vicinity to the IS.
Study context
- Population
- Patients with atrial fibrillation (AF) admitted for acute ischaemic stroke, 2010–20
- Participants
- 720 patients
- Exposure
- AF diagnosed concurrently with stroke vs prior AF
- Prior AFn = 451reference
- AFDCSn = 269
- Outcome
- Net clinical outcome:
- Recurrent stroke
- Major bleeding
- Hospitalization or ED visits for CV events
- Death
- Follow-up
- Median 2.0 (IQR 0.6-4.6) years
Main finding
Net clinical outcome · median 2.0 years
Adjusted hazard ratio
0.776
95% CI 0.611–0.986
P = 0.038
AFDCSvs Prior AF
adjusted HR 0.776 (95% CI 0.611–0.986); P = 0.038
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Recurrent stroke · median 2.0 years | 0.784 (0.450–1.365) | P = 0.389 | |
| 0.512Adjusted hazard ratio (log scale) |
Comorbidities
- Prior AF had more prevalent diabetes, HF, vascular disease and valvular heart disease than AFDCS
- all P < 0.05
Echocardiographic profile
- AFDCS had significantly higher LVEF and smaller left atrial diameter than prior AF
Original publication
Comparative clinical profiles and outcomes of prior vs. concurrently diagnosed atrial fibrillation in acute ischaemic stroke: the implication of diagnosis timing. Europace. Published 3 June 2025. doi:10.
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