Arrhythmias & electrophysiology
Hemolysis Related to Pulsed-field Ablation (PFA): Comparative Study of Next-Generation Nanosecond With Conventional PFA Systems
Authors' conclusion
Hemolysis commonly occurs across PFA procedures, irrespective of pulse duration, and is greater with single-shot than focal systems.
Study context
- Population
- Consecutive patients with atrial fibrillation undergoing first-time PFA67% male, mean age 58.9 ± 11.68
- Participants
- 94 patients
- Exposure
- Hemolysis profiles across different PFA systems
- Nano PFA 360n = 30
- Pentasplinen = 34
- Lattice tipn = 30
- Outcome
- Hemolysis (>10 mg/dL decrease in Hp between T1 and T2)
- Follow-up
- 24 hours after the procedure
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Hemolysis occurred, all patients
88
93.6%
Observational data: associations, not effects.
Further findings
Significant hemolysis (Hp ≤ 25 mg/dL) · 24 hours after the procedure
- Significant hemolysis (haptoglobin (Hp) ≤ 25 mg/dL): P < 0.001
Significant hemolysis, multivariable analysis
- Nano PFA 360 and Pentaspline associated with a similarly high risk of significant hemolysis compared with Lattice tip
- P < 0.001
- No statistically significant difference between Nano PFA 360 and Pentaspline catheters
Baseline and procedural characteristics
- No statistically significant differences among the 3 systems
Original publication
Hemolysis Related to PFA: Comparative Study of Next-Generation Nanosecond With Conventional PFA Systems. JACC Clin Electrophysiol. Published 22 July 2026. doi:10.
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