Comparative Efficacy of Transfusion Strategies in Women and Men With Myocardial Infarction and Anemia: Prespecified Secondary Findings From the MINT Trial
Authors' conclusion
For MINT patients with anemia and AMI, women comprised nearly half of the study population, and randomization to a restrictive or liberal transfusion strategy resulted in comparable outcomes in women and men.
Study context
- Population
- Patients hospitalized with acute MI and anemia1,593 (45.4%) women
- Participants
- 3,504 patients
- Comparison
- Restrictive vs liberal transfusion strategy, by sex
- Primary endpoint
- Composite:
- Death
- MI
- Follow-up
- 30 days
Methodological detailsprespecified
- Prespecified
Primary result
As reported in the abstract
30-day death or MI, by sex
Women
Men
- Primary outcome, women vs men overall
- 15.7% vs 15.7%
- No significant sex × transfusion strategy interaction
- interaction P=0.60
Secondary outcomes
| Outcome | RR (95% CI) | |
|---|---|---|
| 30-day cardiac death, men (subgroup) · men | 2.34 (1.48–3.70) | |
| 0.20.5125Relative risk (log scale) |
- 30-day cardiac death, men (subgroup): interaction P=0.05
Mortality between 30 and 180 days, women vs men
- Lower mortality in women (women vs men)
- 11.0% versus 13.5%; P=0.04
Transfusions received
- Women received fewer transfusions on average
Original publication
Comparative Efficacy of Transfusion Strategies in Women and Men With Myocardial Infarction and Anemia: Prespecified Secondary Findings From the MINT Trial. Circulation. Published 18 May 2026. doi:10.
Summarised from the published abstract; every number is checked against it