Heart failure & cardiomyopathies
Comparison of Blood Volume Profiles in Heart Failure With Preserved and Reduced Ejection Fractions: Sex Makes a Difference
Authors' conclusion
Findings support significant differences in BV, plasma volume, and red blood cell mass profile distributions between heart failure phenotypes, driven in large part by sex-specific factors.
Study context
- Population
- Patients with chronic NYHA II–III heart failure (HF); Blood volume (BV) quantitated by nuclear medicine indicator-dilutionBV analyses in 395 unique patients
- Participants
- 530 patients
- Exposure
- HFrEF vs HFpEF; male vs female
- HF with reduced ejection fractionn = 360
- HF with preserved ejection fractionn = 170reference
- Outcome
- BV, plasma volume and red blood cell mass profiles by HF phenotype and sex
Main finding
As reported in the abstract
Absolute BV
Absolute BV
BV expansion ≥+25% of normal HFrEF 39% · HFpEF 26% · P = 0.003
Normal BV HFrEF 24% · HFpEF 42% · P < 0.001
- HFrEF vs HFpEF: P < 0.001 — absolute BV
- Large variability in volume profiles in both phenotypes (deficit to excess relative to normal)
- −22% deficit to +109% excess
Observational data: associations, not effects.
Further findings
Absolute BV by sex (both phenotypes)
P < 0.001
- Absolute BV by sex (both phenotypes) — Males: higher frequency of large BV and plasma volume expansions above normal
- both P<0.001
- Absolute BV by sex (both phenotypes) — Females: higher prevalence of normal BV and plasma volume
- both P<0.001
Original publication
Comparison of Blood Volume Profiles in Heart Failure With Preserved and Reduced Ejection Fractions: Sex Makes a Difference. Circ Heart Fail. Published 6 June 2024. doi:10.
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