Heart failure & cardiomyopathies
Differences in Red Blood Cell Mass Profiles Impact Intravascular Volume and Outcome Risk in Chronic Heart Failure
Authors' conclusion
Markedly different RBCM profiles are identifiable among comparably compensated heart failure patients, and this variability carries significant implications for post-hospital outcomes. Novel to this analysis and in contrast to RBCM deficit is the independent association of RBCM excess with better event-free survival compared with normal RBCM.
Study context
- Population
- Chronic HF patients at hospital discharge after diuretic treatment for clinical congestion; Red blood cell mass (RBCM) measured by nuclear medicine indicator-dilution
- Participants
- 132 patients
- Exposure
- RBCM deficit vs normal RBCM vs RBCM excess
- Normal RBCMn = 42reference
- RBCM deficitn = 36
- RBCM excessn = 54
- Outcome
- HF-related mortality or first rehospitalization
- Follow-up
- 1 year
Main finding
As reported in the abstract
RBCM excess vs Normal RBCM: P < 0.001 · RBCM deficit vs Normal RBCM: P < 0.001
- Composite outcome events
- 61
- Deaths
- 38 (29% of cohort)
Observational data: associations, not effects.
Further findings
- Dilutional 'anaemia' (Hb <12 g/dL with normal or excess RBCM and plasma volume expansion) — Patients with dilutional 'anaemia' · Dilutional 'anaemia' vs True anaemia · lower risk
- 37 (28%) · P = 0.03
Original publication
Differences in Red Blood Cell Mass Profiles Impact Intravascular Volume and Outcome Risk in Chronic Heart Failure. ESC Heart Fail. Published 30 January 2023. doi:10.
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