Comparison of cardiac troponin assays reveals assay-specific sensitivities in a clinical model of very acute myocardial injury
Authors' conclusion
The Atellica assay demonstrated enhanced sensitivity for very acute myocardial injury, likely via its additional recognition of the proximally located cTnI epitope.
Study context
- Population
- Patients undergoing pulmonary vein isolation (left-atrial ablation) as a clinical model of acute myocardial injuryplus 48 routine post-ablation cohort
- Participants
- 158 patients
- Comparison
- Atellica-IM hs-cTnI vs Architect hs-cTnI vs Elecsys hs-cTnT
- Outcome
- Relative pre-to-post-procedural cTn concentration increase and cTnI/T ratios by assay
Methodological detailsprospective
- Prospective
Performance
As reported in the abstract
Pre-to-post-procedural cTnI concentration increase
Atellica-IM-cTnI
39.6-fold
Architect-cTnI
20.5-fold
P = 0.0036
Further findings
≥1 post-procedural cTn concentration above acute myocardial infarction (AMI) rule-in thresholds
- Patients with ≥1 post-procedural cTn above AMI rule-in thresholds
- 78%
Predictors of pre-to-post increase
- CKD predicted higher pre-to-post increases
Routine clinical cTn after ablation (n = 48, retrospective)
- cTn levels after ablation did not correlate with symptoms, ECG changes or angiography findings
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparison of cardiac troponin assays reveals assay-specific sensitivities in a clinical model of very acute myocardial injury. Eur Heart J Acute Cardiovasc Care. Published 25 April 2025. doi:10.
Summarised from the published abstract; every number is checked against it