Valvular & structural heart disease
Comparison of different percutaneous revascularisation timing strategies in patients undergoing transcatheter aortic valve implantation
Authors' conclusion
In patients with severe aortic stenosis and stable coronary artery disease scheduled for TAVI, performance of PCI after TAVI seems to be associated with improved 2-year clinical outcomes compared with other revascularisation timing strategies.
Study context
- Population
- Transcatheter aortic valve implantation (TAVI) patients with significant, stable coronary artery disease (CAD) at preprocedural workup (REVASC-TAVI registry)
- Participants
- 1,603 patients
- Exposure
- Percutaneous coronary interventions (PCI) after TAVI vs PCI before TAVI vs concomitant PCI
- PCI beforen = 1,052
- PCI after TAVIn = 157
- Concomitantly with TAVIn = 394
- Outcome
- All-cause death; composite of all-cause death, stroke, myocardial infarction (MI) or rehospitalisation for congestive heart failure (CHF)
- Follow-up
- 2 years
Methodological detailsinternational registry, inverse probability treatment weighting (IPTW)-adjusted
- International registry
- IPTW-adjusted
Main finding
As reported in the abstract
| Outcome | PCI before | PCI after TAVI | P value |
|---|---|---|---|
| All-cause death | 20.1% | 6.8% | P < 0.001 |
| Composite endpoint | 30.4% | 17.4% | P = 0.003 |
Observational data: associations, not effects.
Further findings
Landmark analyses (0–30 days and 31–720 days)
- Results confirmed at landmark analyses
Original publication
Comparison of different percutaneous revascularisation timing strategies in patients undergoing transcatheter aortic valve implantation. EuroIntervention. Published 18 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →