Valvular & structural heart disease
Timing and Outcomes of Percutaneous Coronary Intervention (PCI) in Conjunction With Transcatheter Aortic Valve Replacement (TAVR) With Balloon-Expandable Valves
An erratum to this article was published (JACC Cardiovasc Interv, 26 May 2025 ↗)
Authors' conclusion
Patients undergoing concomitant PCI and TAVR had higher major vascular complications, and slightly higher composite of all-cause mortality and stroke compared with those who underwent PCI within 90 days before the TAVR procedure.
Study context
- Population
- Patients with stable CAD undergoing PCI and TAVR with SAPIEN 3 balloon-expandable valves, STS/ACC TVT Registry with Medicare Linkage, 2015–2023
- Participants
- 51,480 patients
- Exposure
- PCI before TAVR vs concomitant PCI and TAVR
- Outcome
- All-cause mortality, stroke, and composite of mortality and stroke
- Follow-up
- Up to 3 years
Methodological detailsregistry-based, propensity-matched
- Registry-based
- Propensity-matched
Main finding
As reported in the abstract
3-year follow-up
| Outcome | PCI before TAVR | Concomitant PCI | P value |
|---|---|---|---|
| All-cause mortality | 38.1% | 38.8% | P = 0.013 |
| Mortality and stroke | 42.8% | 43.5% | P = 0.012 |
Observational data: associations, not effects.
Safety
| Outcome | PCI before TAVR | Concomitant PCI | P value |
|---|---|---|---|
| Major vascular complicationsConcomitant PCI vs PCI before TAVR | 1.4% | 2% | P = 0.003 |
Original publication
Timing and Outcomes of PCI in Conjunction With TAVR With Balloon-Expandable Valves. JACC Cardiovasc Interv. Published 27 January 2025. doi:10.
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