Heart failure & cardiomyopathies
Comprehensive clinical benefit of CCM in HFrEF patients: a win-ratio analysis of FIX-HF-5C randomized trial
Primary result · Hierarchical composite (cardiovascular mortality, HFH, and patient-centred outcomes: peak oxygen consumption, Minnesota Living with Heart Failure Questionnaire score, 6-minute walk distance, NYHA functional class)Result — go to the resultWin ratio 2.48 95% CI 1.76–3.64Authors' conclusion
The win-ratio re-analysis supports and extends the original study results demonstrating a consistent clinical benefit of CCM therapy over OMT across a hierarchical framework integrating event-driven clinical endpoints with patient-centred functional outcomes. The findings, while clinically highly encouraging, are hypothesis-generating and warrant validation in future confirmatory studies.
Study context
- Population
- HFrEF patientsrandomized patients (6364 patient pairs)
- Participants
- 160 patients
- Comparison
- CCM versus OMT
- Primary endpoint
- Hierarchical composite (cardiovascular mortality, heart failure hospitalization (HFH), and patient-centred outcomes:
- Peak oxygen consumption
- Minnesota Living with Heart Failure Questionnaire score
- 6-minute walk distance
- NYHA functional class)
Methodological detailsmulticentre, hierarchical win-ratio, re-analysis
- Multicentre
- Hierarchical win-ratio
- Re-analysis
Primary result
As reported in the abstract
Win ratio
2.48
95% CI 1.76–3.64
P < 0.001
CCMvs OMT
win ratio 2.48 (95% CI 1.76–3.64); P < 0.001
Further findings
Source of wins
- Event-driven clinical endpoints, share of total wins
- 22%
- Patient-centric endpoints, share of total wins
- 56.2%
- CCM consistently outperformed OMT across all hierarchies
Sensitivity analyses
- Win ratios favouring CCM (range)
- 1.52 to 2.42
NYHA class III and IV subgroups
- Treatment effects consistent across NYHA class III and IV subgroups
Original publication
Comprehensive clinical benefit of CCM in HFrEF patients: a win-ratio analysis of FIX-HF-5C randomized trial. ESC Heart Fail. Published 23 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →