Heart failure & cardiomyopathies
Cardiac contractility modulation in heart failure with reduced ejection fraction patients with QRS duration 120–149 ms: Reduction in heart failure hospitalizations and improvement in functional outcome
Authors' conclusion
CCM significantly improved HF control in NYHA class III HFrEF with reduced ejection fraction patients with moderately prolonged QRSd of 120-149 ms. The effect was comparable to that in patients with QRSd <120 ms.
Study context
- Population
- Heart failure with reduced ejection fraction (HFrEF) patients treated with cardiac contractility modulation (CCM-REG Registry)455 analysed
- Participants
- 503 patients
- Exposure
- Cardiac contractility modulation (CCM) in QRSd 120-149 ms vs QRSd <120 ms
- QRSd 120-149 msn = 111
- Outcome
- HF-related hospitalizations, LVEF and quality of life
Methodological detailsFollow-up up to 2 years; hospitalization rates available for 1 year preimplant
- Follow-up up to 2 years; hospitalization rates available for 1 year preimplant
Main finding
As reported in the abstract
HF hospitalization rate, pre- vs postimplant (QRSd 120-149 ms) · up to 2 years
- Preimplant HF hospitalizations, events per patient-year
- 0.90
- Postimplant HF hospitalizations, events per patient-year
- 0.25
- Pre vs postimplant P
- P <.001
Observational data: associations, not effects.
Further findings
Left ventricular ejection fraction (LVEF) change from baseline (QRSd 120-149 ms)
- LVEF improved
- 7% ± 9%
- P = .014 vs baseline
Minnesota Living with HF Questionnaire score change from baseline (QRSd 120-149 ms)
- MLHFQ score improved
- 10 ± 23 points
- P = .010 vs baseline
NYHA class change from baseline (QRSd 120-149 ms)
- NYHA class improved
- 0.5 ± 0.7 classes
- <0.001 vs baseline
Effect sizes vs QRSd <120 ms
- The effect sizes were similar to those in QRSd <120 ms patients
Original publication
Cardiac contractility modulation in heart failure with reduced ejection fraction patients with QRS duration 120–149 ms: Reduction in heart failure hospitalizations and improvement in functional outcome. Heart Rhythm. Published 19 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →