Heart failure & cardiomyopathies
Prevalence and Impact of Recurrent Rejection on Pediatric Heart Transplant Recipients: A PHTS Multi-Institutional Analysis
Authors' conclusion
Although prevalence of RR has decreased, children experiencing RR are at greatly increased risk for losing their graft, particularly those who have recurrent mixed or antibody-mediated rejection.
Study context
- Population
- Pediatric heart transplant recipients, Pediatric Heart Transplant Society database, January 2000–June 20201,035 (17%) with RR
- Participants
- 6,342 recipients
- Exposure
- Recurrent rejection vs 0 or 1 rejection episodes, and by type of recurrent rejection
- RRn = 1,035
- Outcome
- Prevalence of RR and its impact on CAV and graft loss
Methodological detailsregistry (Pediatric Heart Transplant Society database)
- Registry (Pediatric Heart Transplant Society database)
Main finding
As reported in the abstract
| Outcome | RR |
|---|---|
| Freedom from CAV | 96.6% |
| Freedom from graft loss | 56.3% |
Observational data: associations, not effects.
Further findings
Outcomes by type of RR (AMR, ACR, mixed)
Freedom from CAV
Freedom from graft loss
- Outcomes by type of RR (AMR, ACR, mixed) — Freedom from cardiac allograft vasculopathy (CAV) similar regardless of RR type
- P > 0.05
Outcomes by type of RR (AMR, ACR, mixed)
- Freedom from graft loss lower with recurrent mixed or AMR vs recurrent ACR
Black vs White children with RR
- Black children with RR had lower freedom from CAV and graft loss than White children
- P < 0.05 for all
Original publication
Prevalence and Impact of Recurrent Rejection on Pediatric Heart Transplant Recipients: A PHTS Multi-Institutional Analysis. J Am Coll Cardiol. Published 2 October 2024. doi:10.
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