Heart failure & cardiomyopathiesMechanistic study
Computational Modelling of Myocardial Metabolism in Patients with Advanced Heart Failure
- Mechanistic study
- two independent cohorts
- sex- and BMI-matched controls
Authors' conclusion
Computational modelling identified a subset of advanced HF patients with preserved myocardial metabolism despite a similar degree of systolic dysfunction.
Study context
- Population
- Patients with advanced HF, incl. Left ventricular assist device (LVAD) implantation, and non-failing controls136 cardiac biopsies
- Comparison
- Advanced HF vs non-failing controls
- Outcome
- Ability of personalised computational models of myocardial metabolism to assess individual bioenergetic phenotypes and their clinical implications
Main finding
As reported in the abstract
Fatty acid to glucose utilisation ratio associated with reverse cardiac remodelling after LVAD and predictive of LVEF improvement ≥10%: C-index
0.94 [0.81-1.00], p < 0.01
Further findings
System-level simulations
- Fatty acid administration and carnitine supplementation (in those with low mitochondrial carnitine content) identified as potential interventions to restore substrate utilisation
Original publication
Computational Modelling of Myocardial Metabolism in Patients with Advanced Heart Failure. Eur J Heart Fail. Published 15 July 2025. doi:10.1002/ejhf.3746
Summarised from the published abstract; every number is checked against it