Prevention & lipidsCross-sectional study
Concordance of a High Lipoprotein(a) Concentration Among Relatives
- Cross-sectional study
Data collected March 2006 to August 2010; analysed December 2021 to August 2023
Authors' conclusion
The findings of this cross-sectional study suggest that the yield of cascade screening of first-degree relatives of individuals with high Lp(a) levels is over 40%.
Study context
- Population
- UK Biobank participants with measured Lp(a); high Lp(a) defined as ≥125 nmol/L52,418 analysed
- Participants
- 19,899 / 9,715 / 184,764
- Exposure
- First- and second-degree relatives of index participants with high Lp(a) vs unrelated individuals
- First-degree relativesn = 19,899
- Second-degree relativesn = 9,715
- Unrelated individualsn = 184,764reference
- Outcome
- Concordance of high Lp(a) levels in first- and second-degree relatives of index participants with high Lp(a)
Main finding
As reported in the abstract
High Lp(a) in relatives of index participants with high Lp(a)
Each group vs unrelated individualsOdds ratio (95% CI)
First-degree relatives
7.4(6.8–8.1)
Second-degree relatives
3.0(2.7–3.4)
Observational data: associations, not effects.
Further findings
| Outcome | First-degree relatives | Second-degree relatives | Unrelated individuals |
|---|---|---|---|
| Correlation of Lp(a) levels among relative pairs | Spearman ρ 0.45 | Spearman ρ 0.22 | |
| P | P < .001 | P < .001 | Not reported in the abstract |
Concordance by subgroup (eg, prior atherosclerotic cardiovascular disease (ASCVD), postmenopausal women, statin users)
- Concordance generally consistent among subgroups
Original publication
Concordance of a High Lipoprotein(a) Concentration Among Relatives. JAMA Cardiol. Published 1 December 2023. doi:10.1001/jamacardio.2023.3548
Summarised from the published abstract; every number is checked against it