Heart failure & cardiomyopathies
The CONDUCT-AF Trial: Rationale and Design of a Prospective, Randomized, Multicentre Study Comparing Conduction System and Biventricular Pacing in Patients Undergoing Atrioventricular Node Ablation for Heart Failure with Atrial Fibrillation
Study context
- Population
- Heart failure (HF) patients with symptomatic refractory atrial fibrillation (AF), reduced left ventricular ejection fraction (LVEF) and narrow QRS, scheduled for AV node ablationplanned enrolment
- Participants
- 82 patients
- Planned comparison
- Conduction system pacing vs biventricular pacing, with subsequent AV node ablation
- Primary endpoint
- Change in LVEF
- Follow-up
- 6 months
Methodological detailsdesign and rationale, investigator-initiated, prospective, multicentre, non-inferiority, 10 European centres, 1:1 randomisation, Follow-up at least 24 months, Recruitment expected to conclude in 2025; first results anticipated in 2026
- Design and rationale
- Investigator-initiated
- Prospective
- Multicentre
- Non-inferiority
- 10 European centres
- 1:1 randomisation
- Follow-up at least 24 months
- Recruitment expected to conclude in 2025; first results anticipated in 2026
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
The CONDUCT-AF Trial: Rationale and Design of a Prospective, Randomized, Multicentre Study Comparing Conduction System and Biventricular Pacing in Patients Undergoing Atrioventricular Node Ablation for Heart Failure with Atrial Fibrillation. Eur J Heart Fail. Published 8 September 2025. doi:10.
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