Heart failure & cardiomyopathiesSecondary analysis
Ferric Derisomaltose Augments Intrinsic Skeletal Muscle Electron Transport Chain Activity in Heart Failure: A FERRIC-HF II Molecular Substudy
- Secondary analysis of the FERRIC-HF II randomised trial
- molecular substudy
Authors' conclusion
Iron repletion induces an early, selective, and potentially direct enhancement of mitochondrial complex I-dependent respiration in the skeletal muscle of heart failure patients.
Study context
- Population
- Patients with HF (age 66 ± 13 years, 73% men, LVEF 37 ± 8%, 48% NYHA class III, 50% diabetic)
- Participants
- 21 vs 19
- Comparison
- Ferric derisomaltose vs placebo
- Ferric derisomaltose (FDI)n = 21
- Placebon = 19reference
- Primary endpoint
- Skeletal muscle mitochondrial electron transport chain activity (complex I, II and I&II respiration)
- Follow-up
- 2 weeks after randomisation
Primary result
As reported in the abstract
Total complex I-linked respiration · 2 weeks
P = 0.03
Further findings
Net complex I-linked respiration · 2 weeks
P = 0.01
Other respiratory states, complex I-V protein levels, myoglobin, oxidative fibre type content
- No intergroup difference
Original publication
Ferric Derisomaltose Augments Intrinsic Skeletal Muscle Electron Transport Chain Activity in Heart Failure: A FERRIC-HF II Molecular Substudy. Eur J Heart Fail. Published 8 September 2025. doi:10.1002/ejhf.70028
Summarised from the published abstract; every number is checked against it