Acute cardiac care & resuscitationRandomised controlled trial
Conservative Oxygen for Unresponsive Patients after Cardiac Arrest
- Randomised controlled trial
- multicentre
Authors' conclusion
Among unresponsive adults undergoing mechanical ventilation in the ICU after a cardiac arrest, the percentage who survived with a favorable functional outcome was not higher with conservative oxygen therapy than with liberal oxygen therapy.
Study context
- Population
- Unresponsive adults receiving mechanical ventilation in the intensive care unit (ICU) after cardiac arrest
- Participants
- 1,840 adults · 53 ICUs
- Comparison
- Conservative vs liberal oxygen therapy
- Conservative oxygenn = 882
- Liberal oxygenn = 958reference
- Primary endpoint
- Survival with a favorable functional outcome (Glasgow Outcome Scale (GOS-E) level ≥5)
- Follow-up
- 180 days
Primary result
Survival with favorable functional outcome
Relative risk
0.97
95% CI 0.87–1.09
P = 0.65
Events by treatment group
Conservative oxygen vs Liberal oxygen
RR 0.97 (95% CI 0.87–1.09); P = 0.65
As reported in the abstract
Safety
Adverse events
- No adverse events were reported
Original publication
Conservative Oxygen for Unresponsive Patients after Cardiac Arrest. N Engl J Med. Published 10 June 2026. doi:10.1056/nejmoa2513814
Summarised from the published abstract; every number is checked against it