Contribution of Migraine to Cardiovascular Disease Risk Prediction
Authors' conclusion
Adding information on MA status to commonly used CVD risk prediction algorithms enhanced model fit but did not substantially improve risk stratification among women.
Study context
- Population
- Women enrolled in the Women's Health Study, followed for incident cardiovascular disease (CVD)
- Exposure
- Risk models with vs without migraine with aura (MA) status
- Outcome
- Improvement in CVD risk prediction (Harrell c-index, continuous and categorical NRI, IDI) after adding MA status
Methodological detailsrisk prediction analysis, Women's Health Study
- Risk prediction analysis, Women's Health Study
Main finding
As reported in the abstract
Discrimination (Harrell c-index)
| Group | C-index without MA | C-index with MA |
|---|---|---|
| Reynolds Risk Score | 0.792 | 0.797 |
| American Heart Association (AHA)/American College of Cardiology (ACC) pooled cohort equation | 0.793 | 0.798 |
C-index without MA
Reynolds Risk Score0.792
American Heart Association (AHA)/American College of Cardiology (ACC) pooled cohort equation0.793
C-index with MA
Reynolds Risk Score0.797
American Heart Association (AHA)/American College of Cardiology (ACC) pooled cohort equation0.798
- Reynolds Risk Score with MA vs Reynolds Risk Score without MA: P = 0.02 — from 0.792 to 0.797
- AHA/ACC score with MA vs AHA/ACC score without MA: P = 0.01 — from 0.793 to 0.798
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Association of MA with CVD (adjusted)MAvs No MAReynolds Risk Score covariables | 2.09 (1.54–2.84) | |
| Association of MA with CVD (adjusted)MAvs No MAAHA/ACC score covariables | 2.10 (1.55–2.85) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Contribution of Migraine to Cardiovascular Disease Risk Prediction. J Am Coll Cardiol. Published 13 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →