Contributors to high left ventricular ejection fraction in women with ischemia and no obstructive coronary artery disease: Results from the Women's Ischemia Syndrome Evaluation—Coronary Vascular Dysfunction (WISE-CVD) Study
Authors' conclusion
Taken together, these data demonstrate that the majority of women with suspected INOCA have elevated LVEF related to smaller, thicker ventricles with greater contractility.
Study context
- Population
- Women with suspected ischemia with no obstructive coronary disease (INOCA) undergoing CMR
- Participants
- 370 women
- Exposure
- High vs normal vs low left ventricular ejection fraction (LVEF)
- Outcome
- Contributions of LV morphology, function and myocardial perfusion reserve to LVEF
Methodological detailsprospective CMR
- Prospective CMR
Main finding
As reported in the abstract
LVEF category distribution
- High LVEF group had lowest LV cavity volume, greatest LV mass-volume ratio and highest LV end-systolic elastance
- all P < .05
- Age 6 years higher in high LVEF group; other baseline characteristics comparable
- P < 0.01
Observational data: associations, not effects.
Further findings
Myocardial perfusion reserve index
- Low in all groups (mean MPRI < 2.1), not significantly different across LVEF spectrum
- P = 0.458
Original publication
Contributors to high left ventricular ejection fraction in women with ischemia and no obstructive coronary artery disease: Results from the Women's Ischemia Syndrome Evaluation—Coronary Vascular Dysfunction (WISE-CVD) Study. Am Heart J. Published 2 September 2024. doi:10.
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