Arrhythmias & electrophysiology
Reduction of Atrial Fibrillation (AF) Burden After Cryoballoon Ablation in Patients With Early Persistent AF: The COOL-PER Trial
Authors' conclusion
In patients with early persistent AF, cryoablation significantly reduced AF burden and achieved regression of AF type followed by symptom improvement. (Cryoablation for Pulmonary Vein Isolation Alone in Patients with Early Persistent AF Assessed by Continuous Monitoring [COOL-PER]; NCT05507749).
Study context
- Population
- Patients with early persistent AF (≤3 years) undergoing cryoablationpatients enrolled
- Participants
- 130 patients
- Exposure
- AF burden before cryoablation vs 12-month follow-up after cryoablation
- Outcome
- AF burden (percentage of time in AF)
- Follow-up
- 12-month follow-up
Methodological detailsimplantable loop recorder in all patients
- Implantable loop recorder in all patients
Main finding
As reported in the abstract
- AF burden (percentage of time in AF), pre-cryoablation: Mean AF burden before cryoablation 77 ±
- 34%
- AF type before cryoablation (share of patients): high-burden paroxysmal AF
- 25.4%
- AF type before cryoablation (share of patients): implantable loop recorder-confirmed persistent AF
- 74.6%
- AF burden after 12-month follow-up
- 9 ± 21%
- Mean AF burden reduction
- 68 ± 37%
Observational data: associations, not effects.
Further findings
AF recurrence type
- No recurrence of AF
- 38.5%
- Recurrence of paroxysmal AF
- 43.1%
- Recurrence of persistent AF
- 18.5%
Regression to paroxysmal AF or no recurrence, among those with confirmed persistent AF at baseline
- Of those with confirmed persistent AF at baseline, regression to paroxysmal AF or no recurrence
- 76%
AF-related symptoms and quality of life (36-Item Short Form Survey)
- Patients with improved AF-related symptoms and quality of life
- 77%
Original publication
Reduction of AF Burden After Cryoballoon Ablation in Patients With Early Persistent AF: The COOL-PER Trial. JACC Clin Electrophysiol. Published 26 March 2025. doi:10.
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