Coronary calcification in patients presenting with acute coronary syndromes: insights from the MATRIX trial
Primary result · MACEResult — go to the resultHazard ratio 1.91 95% CI 1.66–2.20Authors' conclusion
Patients with ACS and severe coronary calcification, as compared to those without, are associated with worse clinical outcomes irrespective of the management strategy.
Study context
- Population
- Patients presenting with ACS in the MATRIX trial with angiographic calcification dataof 8404 randomised
- Participants
- 7,446 patients
- Comparison
- Severe coronary calcification vs no severe coronary calcification
- Severe calcificationn = 875
- No severe calcificationn = 6,571reference
- Primary endpoint
- Major adverse cardiovascular events (MACE):
- All-cause mortality
- Myocardial infarction (MI)
- Stroke
- Follow-up
- Up to 365 days
Primary result
MACE · 1 year
Hazard ratio
1.91
95% CI 1.66–2.20
P < 0.001
Events by treatment group
Severe calcificationvs No severe calcification
HR 1.91 (95% CI 1.66–2.20); P < 0.001
As reported in the abstract
Further findings
| Outcome | Severe calcification | No severe calcification | HR | P value | |
|---|---|---|---|---|---|
| All-cause mortality | 8.6% | 3.7% | 2.38 (CI 1.84–3.09) | P < 0.001 | |
| MI | 20.1% | 11.5% | 1.81 (95% CI 1.53–2.1) | P < 0.001 | |
| Stroke | 0.8% | 0.6% | 1.35 (95% CI 0.61–3.02) | P = 0.46 | |
| 0.20.5125Hazard ratio (log scale) |
Management strategy
- Fewer PCI and more CABG or medical therapy only with severe calcification
Original publication
Coronary calcification in patients presenting with acute coronary syndromes: insights from the MATRIX trial. Eur Heart J Acute Cardiovasc Care. Published 9 October 2023. doi:10.
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