Coronary disease & ACSMeta-analysis
Titanium-nitride-oxide-coated vs. drug-eluting stents in acute coronary syndromes: an individual patient data meta-analysis
- Systematic review and individual participant data meta-analysis of randomised trials
- mixed-effects Cox regression model
Authors' conclusion
In ACS patients, TiNOS was associated with similar rates of MACE and TLR as compared with DES but significantly lower rates of CD, MI, and stent thrombosis.
Study context
- Population
- Patients presenting with acute coronary syndromes (ACS)
- Participants
- 2,743 patients · 3 RCTs
- Comparison
- TiNOS vs drug-eluting stents (DES)
- TiNOSn = 1,620
- DESn = 1,123reference
- Outcome
- Major adverse cardiac events (MACE):
- Cardiac death
- Myocardial infarction (MI)
- Ischaemia-driven target lesion revascularization (TLR)
- Follow-up
- 5 years
Pooled result
MACE · median follow-up 4.93 years
Hazard ratio
.82
95% CI .67-1.00
P = 0.051
By group
As reported in the abstract
Further pooled results
TLR
HR 1.05 (.80-1.38) · P = 0.733
Cardiac death
HR .46 (.26-.81) · P = 0.007
MI
HR .56 (.42-.75) · P < 0.001
Safety
Stent thrombosis
HR .30 (.17-.53) · P < 0.001
Original publication
Titanium-nitride-oxide-coated vs. drug-eluting stents in acute coronary syndromes: an individual patient data meta-analysis. Eur Heart J. Published 21 February 2025. doi:10.1093/eurheartj/ehaf098
Summarised from the published abstract; every number is checked against it