Coronary flow and resistance patterns indexed by subtended myocardial mass in coronary microvascular dysfunction
Authors' conclusion
Despite significantly lower subtended mass, patients with structural CMD exhibit abnormal indexed Rμ,hyper and Qhyper, supporting the notion of hyperaemic flow restriction at the tissue level that is independent of subtended mass. However, patients with functional CMD have similar subtended myocardial mass to controls and exhibit no flow restriction during hyperaemia.
Study context
- Population
- Patients with angina with non-obstructive coronary arteriesmass and flow analysed in the left anterior descending artery
- Participants
- 100 patients
- Comparison
- Flow and resistance measurements analysed both in absolute terms and after indexing by subtended mass, structural coronary microvascular dysfunction (CMD) and functional CMD vs control
- Outcome
- Mean subtended myocardial mass
Main finding
As reported in the abstract
Structural CMD vs control: P = 0.027 · control vs functional CMD: P = 0.339
Further findings
| Outcome | Control | Structural CMD | Functional CMD | P value | |
|---|---|---|---|---|---|
| Indexed Rμ,hyperControl vs structural CMD · higher with structural CMD · indexed by subtended mass | mean 20.68 (SD 7.99) WUâ¢kg | mean 30.58 (SD 11.63) WUâ¢kg | Not reported in the abstract | P < 0.001 | functional CMD: not reported in the abstract |
| Indexed QhyperControl vs structural CMD · lower with structural CMD · indexed by subtended mass | mean 4.56 (SD 2.20) ml/min/g | mean 3.20 (SD 0.90) ml/min/g | Not reported in the abstract | P = 0.013 | functional CMD: not reported in the abstract |
Indexed Rμ,hyper and Qhyper, functional CMD vs controls
- Patients with functional CMD exhibited similar indexed values of Rμ,hyperand Qhyper to controls
Original publication
Coronary flow and resistance patterns indexed by subtended myocardial mass in coronary microvascular dysfunction. EuroIntervention. Published 18 August 2025. doi:10.
Summarised from the published abstract; every number is checked against it