Rationale and design of European microcirculatory resistance and absolute flow team: The Euro-CRAFT registry
Study context
- Population
- Patients with stable chest pain suggestive of angina and nonobstructive epicardial coronary arteries on invasive coronary angiography, defined as fractional flow reserve >0.80patients enrolled (recruitment September 2022 to May 2025), 671 initially planned based on sample size estimation
- Participants
- 678 patients
- Planned comparison
- Compare the rate of major adverse cardiac and cerebrovascular events (MACCE) in patients with and without coronary microvascular dysfunction (CMD) assessed with Microvascular Resistance Reserve (MRR) at 1 year
- Primary endpoint
- Rate of MACCE in patients with and without CMD assessed with MRR
- Follow-up
- 1 year
Methodological detailsregistry
- Registry
No results yet. This paper sets out the design of a trial; its results are to come.
Further findings
Study recruitment
- Recruitment started in September 2022 and completed in May 2025; total patients enrolled
- 678
Original publication
Rationale and design of European microcirculatory resistance and absolute flow team: The Euro-CRAFT registry. Am Heart J. Published 27 August 2025. doi:10.
Summarised from the published abstract; every number is checked against it