Heart failure & cardiomyopathies
Coronary Microvascular Dysfunction and Left Heart Filling Pressures in Patients with Type 2 Diabetes
Authors' conclusion
In patients with type 2 diabetes without known HFpEF but risk factors for cardiovascular disease, myocardial blood flow rate was independently associated with PCWP at rest across the range from normal to abnormal left heart filling pressures.
Study context
- Population
- Patients with T2DM at high risk of CV events, without known heart failure with preserved ejection fraction (HFpEF)
- Participants
- 37 patients
- Outcome
- Factors associated with LV filling pressure (PCWP) at rest and during exercise
Methodological detailsRight heart catheterization at rest and during exercise, echocardiography, UACR and 82Rb-PET/CT quantification of MFR
- Right heart catheterization at rest and during exercise, echocardiography, UACR and 82Rb-PET/CT quantification of MFR
Main finding
As reported in the abstract
Independent factors associated with PCWP at rest
- History of hypertension: coefficient 2.6 mmHg [0.3; 5.0]
- P = 0.030
- MFR independently associated with pulmonary capillary wedge pressure (PCWP)
- P = 0.026
Observational data: associations, not effects.
Further findings
Invasive criteria for HFpEF
- Patients meeting invasive HFpEF criteria
- 22 (59%)
Factors associated with PCWP during exercise (borderline)
- Myocardial flow reserve: coefficient −4.4 [−9.6; 0.8]
- P = 0.091
- Beta-blocker use: coefficient 6.1 [−0.1; 12.4]
- P = 0.053
Original publication
Coronary Microvascular Dysfunction and Left Heart Filling Pressures in Patients with Type 2 Diabetes. ESC Heart Fail. Published 28 July 2024. doi:10.
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