Heart failure & cardiomyopathiesDiagnostic or prognostic study
Prediction of Left Ventricular Filling Pressures Using Natural Shear Waves
- Diagnostic accuracy study
- prospective
Authors' conclusion
In comparison with the multivariable guideline approach, end-diastolic shear wave velocity as a single measure had similar accuracy in detecting elevated LVMDP and a higher accuracy for LVEDP.
Study context
- Population
- Patients with invasively measured left ventricular (LV) filling pressures (left ventricular mid-diastolic pressure (LVMDP), left ventricular end-diastolic pressure (LVEDP))
- Participants
- 85 patients
- Comparison
- Shear wave velocity at mitral valve closure (MVC) vs conventional echocardiographic parameters and the 2021 guideline algorithm
- Outcome
- Relation of shear wave velocity at MVC to invasively measured LVFP
Performance
As reported in the abstract
Detection of elevated LVFP
| Test or model | r with LVEDP | AUC LVMDP | Sensitivity LVMDP | Specificity LVMDP | AUC LVEDP | Sensitivity LVEDP | Specificity LVEDP | Pearson r with LVFP | AUC |
|---|---|---|---|---|---|---|---|---|---|
| Shear wave velocity at MVC | 0.71 | 0.79 | 87% | 65% | 0.95 | 92% | 94% | ||
| Conventional echocardiographic parameters | 0.39 and 0.58 | 0.66 and 0.79 | |||||||
| Guideline algorithm | 0.78 | 0.60 |
Further findings
Shear wave velocity in acutely decompensated HF, admission vs after diuretic therapy · significant decrease
P < 0.002
- Shear wave velocity in acutely decompensated HF, admission vs after diuretic therapy: n = 16
Original publication
Prediction of Left Ventricular Filling Pressures Using Natural Shear Waves. JACC Cardiovasc Imaging. Published 30 July 2025. doi:10.1016/j.jcmg.2025.04.009
Summarised from the published abstract; every number is checked against it