Coronary microvascular health in symptomatic patients with prior COVID-19 infection: an updated analysis
Authors' conclusion
The prevalence of impaired MFR is similar by duration of time from infection up to 1 year and SARS-CoV-2 variants, but significantly differs by severity of infection.
Study context
- Population
- Symptomatic patients with clinically indicated positron emission tomography (PET) imaging (mean age 65 ± 12 years, 52% men)matched 1:3
- Participants
- 271 vs 815
- Comparison
- Prior COVID-19 vs no prior infection
- Casesn = 271
- Controlsn = 815reference
- Outcome
- Impaired myocardial flow reserve (MFR <2)
Methodological detailsMedian (IQR) time from COVID-19 to PET: 174 (58-338) days
- Median (IQR) time from COVID-19 to PET: 174 (58-338) days
Main finding
As reported in the abstract
Impaired MFR (MFR <2)
- Results similar in clinically meaningful subgroups
Observational data: associations, not effects.
Further findings
Impaired myocardial flow reserve (MFR) in clinically meaningful subgroups
- Results similar in clinically meaningful subgroups
Proportion of cases with MFR <2 by time from infection, variant and severity
- Peaked 6-9 months from imaging, with a non-significant downtrend afterwards
- Comparable across SARS-CoV-2 variants
- Increased with increasing severity of infection
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Coronary microvascular health in symptomatic patients with prior COVID-19 infection: an updated analysis. Eur Heart J Cardiovasc Imaging. Published 31 May 2023. doi:10.
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