The prognostic interplay of coronary artery calcium volume and density with myocardial flow reserve and incident cardiovascular events
Authors' conclusion
At any level of CAC volume, higher CAC density is significantly associated with higher MFR but not associated with risk of death/myocardial infarction.
Study context
- Population
- Consecutive patients referred for clinically indicated positron emission tomography (PET) myocardial perfusion imaging between 2019 and 2024, excluding coronary artery calcium (CAC) = 0 and known coronary artery disease
- Participants
- 3,884 patients
- Comparison
- CAC volume and density in relation to PET-derived myocardial flow reserve (MFR) and incident death/myocardial infarction
- Outcome
- Death/myocardial infarction
- Follow-up
- Median 13.7 months
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Hazard ratio (95% CI)
CAC densityinversely associated; model with CAC volume and density, demographics and cardiovascular risk factors
0.67(0.47–0.96)
CAC volumepositively associated; same model
1.57(1.34–1.82)
- Primary outcome occurred
- 218 individuals (5.6%)
Further findings
MFR
| β coefficient (95% CI) | |
|---|---|
| CAC densityPositively associated; CAC volume and density in same model | 0.10 (0.06–0.15) |
| CAC volumeInversely associated | −0.08 (−0.10 to −0.05) |
Age
- Mean (SD) age
- 69 (±10.5) years
Original publication
The prognostic interplay of coronary artery calcium volume and density with myocardial flow reserve and incident cardiovascular events. Eur Heart J Cardiovasc Imaging. Published 8 May 2025. doi:10.
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