Coronary Plaque in People With HIV vs Non-HIV Asymptomatic Community and Symptomatic Higher-Risk Populations
Authors' conclusion
Asymptomatic PWH in REPRIEVE had more plaque than asymptomatic PwoH in SCAPIS but had similar prevalence to a higher-risk stable chest pain cohort in PROMISE. In PWH, CAC = 0 does not reliably exclude plaque.
Study context
- Population
- Nonstatin users without known coronary plaques with coronary CT
- Participants
- 755 / 23,558 / 2,291
- Exposure
- People with HIV (PWH) vs asymptomatic community PwoH vs stable chest pain PwoH
- REPRIEVEn = 755
- SCAPISn = 23,558reference
- PROMISEn = 2,291
- Outcome
- Coronary plaque prevalence on coronary CT
Methodological detailscomparison of 3 cohorts
- Comparison of 3 cohorts
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
CAC = 0 prevalence
Plaque prevalence among CAC = 0 (subgroup) — REPRIEVE vs SCAPIS · vs PwoH cohorts
P < 0.001
Age — REPRIEVE vs SCAPIS · vs SCAPIS and PROMISE
P < 0.001
| Outcome | REPRIEVE | SCAPIS | PROMISE | P value |
|---|---|---|---|---|
| 10-year ASCVD riskREPRIEVE vs SCAPIS · vs SCAPIS and PROMISE | 5.0% (SD 3.2%) | 6.0% (SD 5.3%) | 13.5% (SD 11.0%) | P < 0.001 |
Plaque prevalence stratified by atherosclerotic cardiovascular disease (ASCVD) risk
- PWH had more plaque vs SCAPIS and similar prevalence vs PROMISE
Original publication
Coronary Plaque in People With HIV vs Non-HIV Asymptomatic Community and Symptomatic Higher-Risk Populations. JACC Adv. Published 3 May 2024. doi:10.
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