Coronary disease & ACS

Prognostic Value of Microvascular Resistance Reserve After Percutaneous Coronary Intervention in Patients With Myocardial Infarction

J Am Coll CardiolPublished Pooled analysis of individual patient data from 6 cohorts

Pooled resultResult — go to the resultHazard ratio 4.16 95% CI 2.31–7.50

Authors' conclusion

MRR measured directly after primary percutaneous coronary intervention was an independent predictor of the composite of all-cause mortality or hospitalization for heart failure during long-term follow-up.

Study context

Population
Patients with STEMI with index of microcirculatory resistance (IMR) and microvascular resistance reserve (MRR) measured directly after primary PCIpooled cohort n = 1,265
Participants
446 patients
Comparison
Low MRR vs high MRR after primary PCI
Outcome
Composite of:
  • All-cause mortality
  • Hospitalization for HF
Follow-up
Median 3.1 years (Q1-Q3: 1.5-6.1 years)
Methodological detailssubgroup analysis
  • Subgroup analysis

Pooled result

As reported in the abstract

Hazard ratio

4.16

95% CI 2.31–7.50

P < 0.001

By group

Low MRRvs High MRR
HR 4.16 (95% CI 2.31–7.50); P < 0.001

Further pooled results

Independent predictors of the primary endpoint

Both IMR and MRR were independent predictors of all-cause mortality or HF hospitalization

Original publication

Prognostic Value of Microvascular Resistance Reserve After Percutaneous Coronary Intervention in Patients With Myocardial Infarction. J Am Coll Cardiol. Published 3 May 2024. doi:10.1016/j.jacc.2024.02.052

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