Heart failure & cardiomyopathies
Unipolar Voltage Mapping to Predict Recovery of Left Ventricular Ejection Fraction in Patients With Recent-Onset Nonischemic Cardiomyopathy
Authors' conclusion
Left ventricular unipolar voltage abnormality is a potent predictor of LVEF recovery among patients recently diagnosed with nonischemic cardiomyopathy.
Study context
- Population
- Patients with recent-onset nonischemic cardiomyopathy (left ventricular ejection fraction (LVEF) ≤45% and HF symptoms or signs within the past 6 months), 2017–2020
- Participants
- 29 patients
- Comparison
- Recovery vs No Recovery of LVEF by LV endocardial unipolar voltage abnormality
- Recoveryn = 13
- Primary endpoint
- Recovery of LVEF (1-year LVEF ≥50% or ≥45% with ≥10% increase from baseline)
- Follow-up
- 1 year
Methodological detailsnonrandomized, 2 institutions
- Nonrandomized
- 2 institutions
Primary result
As reported in the abstract
Percent endocardial surface area with unipolar voltage abnormality (AUA)
P = 0.004
- LVEF recovered by 1 year
- 13 (44.8%)
- Percent AUA and likelihood of Recovery: OR per 10% increase in AUA
- 0.64 (95% CI 0.47-0.88; P=0.006)
- 28% AUA cutoff for predicting recovery: sensitivity
- 92%
- 28% AUA cutoff: specificity
- 75%
- 28% AUA cutoff: AUC
- 0.81 (95% CI 0.63-0.99; P=0.001)
- Patients with AUA >28% who did not recover
- 12 of 13; 92.3%
Original publication
Unipolar Voltage Mapping to Predict Recovery of Left Ventricular Ejection Fraction in Patients With Recent-Onset Nonischemic Cardiomyopathy. Circulation. Published 14 November 2024. doi:10.
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