Arrhythmias & electrophysiology
Cryoballoon Ablation in Older Patients With Heart Failure: Insights From a Large-Scale Multicenter Clinical Study
Authors' conclusion
CBA for AF in older patients with HF is feasible and improves cardiac parameters
Study context
- Population
- Patients with heart failure (HF) and atrial fibrillation (AF) undergoing cryoballoon ablation (CBA)of 3,655 undergoing CBA
- Participants
- 549 patients
- Exposure
- CBA in older vs younger patients with HF
- Oldern = 185
- Youngern = 364reference
- Outcome
- Recurrence, mortality and HF hospitalization after CBA
- Follow-up
- Median 21.5 (12.0-37.0) months
Methodological details17 institutions
- 17 institutions
Main finding
As reported in the abstract
Recurrence-free survival, mortality, HF hospitalization
| Group | HF hospitalization |
|---|---|
| Older | 4.0 per 100 patient-years |
| Younger | 1.5 per 100 patient-years |
HF hospitalization
Older4.0 per 100 patient-years
Younger1.5 per 100 patient-years
- Older vs Younger: P = 0.008 — HF hospitalization higher in older
Observational data: associations, not effects.
Further findings
- Left ventricular ejection fraction (LVEF) change after ablation (Older)
- 57.4% · LVEF before · LVEF after 60.0%
- BNP change after ablation (Older)
- 173 [113-292] · BNP before · BNP after 87.8 [42-218]
AF recurrence and HF hospitalization
- AF recurrence and HF hospitalization closely linked; most hospitalizations after a year postablation
Safety
Major procedural complications
P = 0.670
Original publication
Cryoballoon Ablation in Older Patients With Heart Failure: Insights From a Large-Scale Multicenter Clinical Study. JACC Adv. Published 29 October 2025. doi:10.
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