Cumulative effect of hyperglycemia and insulin resistance on cardiac dysfunction: The coronary artery risk development in young adults (CARDIA) study
Authors' conclusion
We found that cumulative hyperglycemia is associated with midlife diastolic dysfunction in patients with early-onset T2D, and sustained IR negatively affects systolic and diastolic function regardless of T2D status.
Study context
- Population
- Young adults with or without type 2 diabetes (T2D)/prediabetes who had repeated measures of fasting glucose (FG) and insulin resistance (IR) and echocardiography assessment
- Participants
- 279 vs 514
- Comparison
- Cumulative fasting glucose (FG) and insulin resistance (IR) over 20 years and midlife cardiac dysfunction
- T2D/prediabetesn = 279
- Euglycemicn = 514
- Outcome
- Midlife diastolic dysfunction
Methodological detailsCARDIA, matched
- CARDIA
- Matched
Main finding
As reported in the abstract
- Cumulative hyperglycemia is associated with midlife diastolic dysfunction in patients with early-onset T2D
Further findings
- Sustained IR negatively affects systolic and diastolic function regardless of T2D status
Original publication
Cumulative effect of hyperglycemia and insulin resistance on cardiac dysfunction: The coronary artery risk development in young adults (CARDIA) study. Am Heart J. Published 17 September 2025. doi:10.
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