Cumulative exposure to atherogenic lipoprotein particles in young adults and subsequent incident atherosclerotic cardiovascular disease
Authors' conclusion
Cumulative exposure to atherogenic lipid particles in young adulthood increases the risk for incident ASCVD later in life.
Study context
- Population
- Young adults aged 18 to <40 years, CARDIA cohort241 atherosclerotic cardiovascular disease (ASCVD) events
- Participants
- 4,366 adults
- Exposure
- Per 1 SD higher cumulative apolipoprotein B (apoB), low-density lipoprotein particle (LDL-P) and triglyceride-rich lipoprotein particle (TRL-P) exposure in young adulthood
- Outcome
- Incident ASCVD after age 40
- Follow-up
- Mean 19.3 years
Methodological detailslongitudinal, population-based
- Longitudinal
- Population-based
Main finding
As reported in the abstract
Incident ASCVD after age 40, per 1 SD higher cumulative exposure
Hazard ratio (95% CI)
apoB (per 1 SD)
1.53(1.36–1.72)
LDL-P (per 1 SD)
1.54(1.36–1.75)
TRL-P (per 1 SD)
1.48(1.30–1.68)
Per 1 SD, as printed
- Adjusted HRs for each measure approximately
- 1.30
Observational data: associations, not effects.
Further findings
Usual apoB exposure threshold
- HR for ASCVD increased after usual apoB exposure of approximately
- 75 mg/dL/year
Original publication
Cumulative exposure to atherogenic lipoprotein particles in young adults and subsequent incident atherosclerotic cardiovascular disease. Eur Heart J. Published 4 July 2025. doi:10.
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