Prevention & lipidsCohort study
Apolipoprotein B outperforms low density lipoprotein particle number as a marker of cardiovascular risk in the UK Biobank
- Prospective cohort study
Authors' conclusion
This study suggests that ApoB is a more accurate marker for cardiovascular risk than LDL-P when discordant, as marked by ApoB levels in excess of LDL-P.
Study context
- Population
- UK Biobank adults with ≥10 years of data, ≥3 ICD codes, plasma lipoprotein and apolipoprotein measurements (mean age 57 years, 49.7% female, 95.1% white)
- Participants
- 41,099 adults
- Exposure
- Discordant Apolipoprotein B (ApoB) vs LDL-P subpopulations vs concordant group
- Outcome
- MACE and CAD events
- Follow-up
- 10 years
Main finding
As reported in the abstract
MACE and CAD events by ApoB/LDL-P discordance · 10 years
- Major adverse cardiovascular events (MACE), 2% discordance, vs concordant control
- HR 1.1; P < 0.0001
- Coronary artery disease (CAD), 2% discordance, vs concordant control
- HR 1.1; P < 0.0001
HR
- ApoB discordance at 30%: MACE
- 1.4
- ApoB discordance at 30%: CAD
- 2.5
Observational data: associations, not effects.
Original publication
Apolipoprotein B outperforms low density lipoprotein particle number as a marker of cardiovascular risk in the UK Biobank. Eur J Prev Cardiol. Published 1 September 2025. doi:10.1093/eurjpc/zwaf554
Summarised from the published abstract; every number is checked against it