Current Practice and Safety of Invasive Coronary Function Testing: A Nationwide Multicenter Survey in Japan
Authors' conclusion
This large-scale survey confirms the feasibility and safety of invasive CFT, even in emergency settings.
Study context
- Population
- Patients undergoing invasive coronary function testing at institutions of the Japanese Cardiovascular Intervention and Therapeutics Society, January 2022–December 2023235 institutions
- Participants
- 4,700 / 2,283 / 2,192
- Exposure
- Acetylcholine (ACh) vs ergonovine (ERG) provocation tests; emergency vs elective settings
- AChn = 4,700
- ERGn = 2,283
- Coronary flow reserve (CFR)/index of microcirculatory resistance (IMR)n = 2,192
- Outcome
- Current practice, diagnostic yield and safety of invasive coronary function testing
Methodological detailsnationwide survey, 235 institutions
- Nationwide survey
- 235 institutions
Main finding
As reported in the abstract
Positivity rate
Observational data: associations, not effects.
Further findings
Abnormal CFR/IMR findings, emergency vs elective
P < 0.001
Safety
| Outcome | ACh | ERG | CFR/IMR | |
|---|---|---|---|---|
| Major complications of provocation tests | 1.4% | 0.4% | Not reported in the abstract | CFR/IMR: not reported in the abstract |
- Complications of CFR/IMR measurement
- 0.05%
Major complications of provocation tests
- No significant difference between emergency and elective settings
Original publication
Current Practice and Safety of Invasive Coronary Function Testing: A Nationwide Multicenter Survey in Japan. JACC Adv. Published 22 December 2025. doi:10.
Summarised from the published abstract; every number is checked against it