International study of coronary microvascular angina (iCorMicA): A registry-based diagnostic study and nested randomized trial

Ang, D; Young, R; Taggart, D; Carrick, D; Chattopadhyay, S; Raja, Y; Balachandran, K; Elghamaz, A; Greenwood, J; Hoole, S; Cotton, J; Choudhury, A; O'Kane, P; Jadhav, S; Purcell, I; Mitra, R; Sabra, A; Giblett, J; Byrne, R; O'Gallagher, K; Subkovas, E; Rampat, R; Anantharam, B; Radhakrishnan, A; Owens, C; Damman, P; Guzik, B; Collison, D; Howarth, F; Lennon, L; Tolentino, PM; Vicere, A; Martin, K; Kamdar, A; Sykes, R; Hanna, R; Tan, D; Heggie, R; Wu, O; Welsh, P; Ford, T; Lang, CC; Kunadian, V; McConnachie, A; Berry, C

doi:10.1016/j.ahj.2026.107527

International study of coronary microvascular angina (iCorMicA): A registry-based diagnostic study and nested randomized trial

Am Heart JPublished 6 Jul 2026international, multicenter, prospective, registry-based study and nested, randomized, controlled, triple-blind, and endpoint trial

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Study context

Population: Patients with angina undergoing invasive management (coronary angiography); participants without obstructive coronary artery disease eligible for randomizationenrolled into the registry · randomized 1,047 · not randomized (registry-only) 386
Participants: 1,483 patients

Planned comparison: Coronary function test-guided management vs results not disclosed
Primary endpoint: Within-individual change in Seattle Angina Questionnaire summary score (randomized trial)
Follow-up: 12-months from baseline

Methodological detailsParticipants, community care providers, and outcomes assessors are masked

Participants, community care providers, and outcomes assessors are masked

No results yet. This paper sets out the design of a trial; its results are to come.

Further findings

Study conduct

First patient screened: December 18, 2020
Last patient enrolled: June 30, 2026
Sites: Forty
United Kingdom: n = 35
Republic of Ireland: n = 2
Holland: n = 2
Poland: n = 1

Reference

Authors: Ang D, Young R, Taggart D, Carrick D, Chattopadhyay S, Raja Y, et al.
All 45 authors
Ang D, Young R, Taggart D, Carrick D, Chattopadhyay S, Raja Y, Balachandran K, Elghamaz A, Greenwood J, Hoole S, Cotton J, Choudhury A, O'Kane P, Jadhav S, Purcell I, Mitra R, Sabra A, Giblett J, Byrne R, O'Gallagher K, Subkovas E, Rampat R, Anantharam B, Radhakrishnan A, Owens C, Damman P, Guzik B, Collison D, Howarth F, Lennon L, Tolentino PM, Vicere A, Martin K, Kamdar A, Sykes R, Hanna R, Tan D, Heggie R, Wu O, Welsh P, Ford T, Lang CC, Kunadian V, McConnachie A, Berry C
Journal: American Heart Journal
Published: 6 Jul 2026
DOI: 10.1016/j.ahj.2026.107527
PubMed: 42409349
Registration: NCT04674449

Countries: Ireland, Netherlands, Poland and United Kingdom
Topic: Coronary disease & ACS
Also indexed: Cardiovascular imaging

Intervention details

intervention: Index of microcirculatory resistance (IMR) and coronary flow reserve (CFR) results disclosed to the attending cardiologist
control group: IMR and CFR results not disclosed to the attending cardiologist

Original publication

International study of coronary microvascular angina (iCorMicA): A registry-based diagnostic study and nested randomized trial. Am Heart J. Published 6 July 2026. doi:10.1016/j.ahj.2026.107527

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Summarised from the published abstract; every number is checked against it