CYP2C19 Genotype Prevalence and Association With Recurrent Myocardial Infarction in British–South Asians Treated With Clopidogrel
Main finding · Recurrent MIResult — go to the resultOdds ratio 3.1Study context
- Population
- British Bangladeshi and Pakistani ancestry participants of the Genes & Health cohort
- Participants
- 44,396 participants
- Exposure
- CYP2C19 poor metabolizers vs other metabolizer status, in clopidogrel-treated patients
- Outcome
- Prevalence of common CYP2C19 genotype polymorphisms and association with recurrent MI in participants prescribed clopidogrel
Methodological detailsmultivariable logistic regression, genetically inferred metabolizer status
- Multivariable logistic regression
- Genetically inferred metabolizer status
Main finding
Recurrent MI
Odds ratio
3.1
P = 0.019
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
Clopidogrel prescription after acute MI
- Proportion of cohort with acute MI prescribed clopidogrel
- 69%
Original publication
CYP2C19 Genotype Prevalence and Association With Recurrent Myocardial Infarction in British–South Asians Treated With Clopidogrel. JACC Adv. Published September 2023. doi:10.
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