Heart failure & cardiomyopathies
Decreased left ventricular systolic function during the late phase after response to cardiac resynchronization therapy
Authors' conclusion
Despite an initial response to CRT, a subset of patients with HF developed DNRR, which correlated with worse clinical outcomes. Identifying risk factors associated with DNRR may help optimize CRT management and improve long-term patient care.
Study context
- Population
- Patients with heart failure (HF) undergoing cardiac resynchronization therapy (CRT) device implantation; responders analyzed for delayed negative reverse remodeling (DNRR)patients undergoing CRT device implantation analyzed, 100 responders · responders 100
- Participants
- 203 patients
- Comparison
- DNRR vs non-DNRR among CRT responders
- DNRRn = 22
- non-DNRRn = 78
- Outcome
- DNRR among responders
- Follow-up
- 1 year after treatment response determination
Main finding
As reported in the abstract
Further findings
Independent predictors of DNRR (multivariate analysis) · 6 months after CRT device implantation
| OR | P value | |
|---|---|---|
| LV end-systolic volume ≥ 100 mLOdds of DNRR | 3.575 | P = 0.041 |
| Paced QRS duration ≥ 150 msOdds of DNRR | 4.427 | P = 0.023 |
| Synchronized LV pacing rate < 85%Odds of DNRR | 5.753 | P = 0.043 |
| Intraventricular conduction disturbanceOdds of DNRR | 5.593 | P = 0.018 |
| Outcome | DNRR | non-DNRR |
|---|---|---|
| LVEF change | from 41.2%±8.3% to 32.7%±9.6% | from 42.8%±9.5% to 46.2%±10.5% |
| P | P<.001 | P<.001 |
Clinical outcomes including cardiac death and HF-related hospitalization
- Significantly worse outcomes in the DNRR group than in the non-DNRR group
Original publication
Decreased left ventricular systolic function during the late phase after response to cardiac resynchronization therapy. Heart Rhythm. Published 6 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →