Valvular & structural heart disease
Sex-specific outcomes after transcatheter or surgical treatment of aortic valve stenosis: the DEDICATE-DZHK6 trial
Authors' conclusion
Among patients with severe aortic stenosis at low to intermediate risk, TAVI was non-inferior to SAVR for the primary outcome in women and men with lower event rates in patients assigned to TAVI.
Study context
- Population
- Low- to intermediate-risk patients with severe aortic stenosis; women and men43.3% women
- Participants
- 1,394 participants
- Comparison
- Transcatheter aortic valve implantation (TAVI) vs surgical aortic valve replacement (SAVR), by sex
- Primary endpoint
- All-cause death or stroke
- Follow-up
- 1 year
Methodological detailspredefined descriptive subgroup analysis
- Predefined descriptive subgroup analysis
Primary result
As reported in the abstract
All-cause death or stroke, by sex
TAVI vs SAVRHazard ratio (95% CI)
Women: 5.2% vs 11.5%
0.46(0.25–0.82)
Men: 5.4% vs 9.0%
0.61(0.35–1.03)
Further findings
| Outcome | TAVI | SAVR | HR (95% CI) | |
|---|---|---|---|---|
| All-cause death, by sex (subgroup) · 1 yearWomen | 2.6% | 6.7% | 0.41 (0.17–0.90) | |
| All-cause death, by sex (subgroup) · 1 yearMen | 2.6% | 5.9% | 0.44 (0.20–0.88) | |
| 0.10.31310Hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Sex-specific outcomes after transcatheter or surgical treatment of aortic valve stenosis: the DEDICATE-DZHK6 trial. Eur Heart J. Published 3 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →