Heart failure & cardiomyopathies

Delta QRS and outcomes post cardiac resynchronization therapy (CRT) in the Resynchronization-Defibrillation for Ambulatory Heart Failure Trial

Heart RhythmPublished Secondary analysis of the RAFT randomised trial

Primary resultResult — go to the resultHazard ratio 1.012 95% CI 1.008–1.017

Authors' conclusion

For patients receiving CRT for heart failure with left ventricular systolic dysfunction and QRS prolongation, ΔQRSd was an independent predictor of long-term mortality and heart failure hospitalization.

Study context

Population
Patients with LV systolic dysfunction and prolonged QRS who received CRT in RAFT, with ECGs at baseline and after implantationRAFT randomized 1798
Participants
813 patients
Comparison
ΔQRSd after CRT as predictor of outcomes
  • ΔQRSd ≤0n = 447
Primary endpoint
Composite of:
  • Death
  • HF hospitalization

Primary result

As reported in the abstract

Hazard ratio

1.012

95% CI 1.008–1.017

ΔQRSd
HR 1.012 (95% CI 1.008–1.017)

Further findings

ΔQRSd distribution · after implantation

Median ΔQRSd
−2 ms (−20 to 18 ms)
ΔQRSd ≤0
447 (55%)

Original publication

Delta QRS and outcomes post CRT in the Resynchronization-Defibrillation for Ambulatory Heart Failure Trial. Heart Rhythm. Published 10 October 2024. doi:10.1016/j.hrthm.2024.10.011

Composed by AI from the published abstract and checked against it. How Briefs are made →

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