Heart failure & cardiomyopathies
Depressive Symptoms are Associated with Clinical Outcomes in Heart Failure with Reduced Ejection Fraction
Authors' conclusion
This study confirms that elevated depressive symptoms are associated with an increased likelihood of adverse clinical outcomes in patients with HFrEF.
Study context
- Population
- Men and women with heart failure and reduced ejection fraction (HFrEF) enrolled through heart failure (HF) clinics
- Participants
- 142 men
- Exposure
- Higher vs lower depressive symptoms
- Outcome
- Death or CV hospitalization
- Follow-up
- Median 4 years
Main finding
As reported in the abstract
Risk of death or CV hospitalization per 10-point higher baseline Beck Depression Inventory-II (BDI-II) score
35% greater
Died
42
30%
CV hospitalizations
84
60%
Observational data: associations, not effects.
Further findings
Baseline BDI-II and health behaviours
- Correlation with HF self-care maintenance (Self-Care of Heart Failure Index (SCHFI))
- R = −0.30, P < 0.001
- Correlation with daily steps
- R = −0.19, P = 0.04
BNP change over 6 months
- Correlation of BDI-II change with BNP change
- R = 0.25, P = 0.004
- Increases in plasma BNP associated with worse outcomes
Original publication
Depressive Symptoms are Associated with Clinical Outcomes in Heart Failure with Reduced Ejection Fraction. ESC Heart Fail. Published 7 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →