Design and pilot results from the Million Veteran Program Return Of Actionable Results (MVP Return of Actionable Results (MVP-ROAR)) Study
Authors' conclusion
While underscoring the importance of clinical confirmation of research results, the pilot phase of the MVP-ROAR Study marks a turning point in MVP and demonstrates the feasibility of returning genetic results to participants and their providers.
Study context
- Population
- Million Veteran Program (MVP) participants with probable pathogenic low-density lipoprotein receptor (LDLR) variants on the MVP genotype array (familial hypercholesterolemia)
- Comparison
- Return of actionable familial hypercholesterolemia (FH) genetic results with telegenetic counseling
- Primary endpoint
- Change in low-density lipoprotein cholesterol (LDL-C) (RCT: results at baseline vs after 6 months)
- Follow-up
- 6 months
Methodological detailswith design of an ongoing randomised controlled trial, single-arm pilot phase, ongoing randomized clinical trial (RCT)
- With design of an ongoing randomised controlled trial
- Single-arm pilot phase
- Ongoing RCT
Primary result
As reported in the abstract
6-month ΔLDL-C after genetic counseling intervention (pilot phase, single arm)
Six-month ΔLDL-C after the genetic counseling intervention
−37 mg/dL
95% CI −12 to −61P = .03
Further findings
| Outcome | Values |
|---|---|
| Active statin prescriptions · 6 months | Pilot 100% |
Results shared with first-degree family members
- First-degree family members receiving results
- 16
Original publication
Design and pilot results from the Million Veteran Program Return Of Actionable Results (MVP-ROAR) Study. Am Heart J. Published 17 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →