Coronary disease & ACS

Design and rationale of randomized evaluation of decreased usage of beta-blockers after acute myocardial infarction (REDUCE-AMI)

Eur Heart J Cardiovasc PharmacotherPublished Design and rationale of a randomised controlled trial

Study context

Population
Patients with acute myocardial infarction (MI) who have undergone coronary angiography and have preserved ejection fraction (EF) (≥50%)about 5000 planned
Planned comparison
Long-term oral beta-blockade vs no beta-blockade
Primary endpoint
Composite of:
  • All-cause death
  • New non-fatal MI
Methodological detailsregistry-based, parallel, open-label, multicentre, 38 centres in Sweden, 1 in Estonia, 6 in New Zealand
  • Registry-based
  • Parallel
  • Open-label
  • Multicentre
  • 38 centres in Sweden, 1 in Estonia, 6 in New Zealand

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

Design and rationale of randomized evaluation of decreased usage of beta-blockers after acute myocardial infarction (REDUCE-AMI). Eur Heart J Cardiovasc Pharmacother. Published 13 December 2022. doi:10.1093/ehjcvp/pvac070

Summarised from the published abstract; every number is checked against it

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