Acute cardiac care & resuscitation
The design of the PRINCESS 2 trial: A randomized trial to study the impact of ultrafast hypothermia on complete neurologic recovery after out-of-hospital cardiac arrest with initial shockable rhythm
Study context
- Population
- Out-of-hospital cardiac arrest (OHCA) patients with initial shockable rhythmplanned sample size
- Participants
- 1,022 patients
- Planned comparison
- Ultrafast hypothermia vs standard normothermia care
- Primary endpoint
- Survival with complete neurologic recovery (modified Rankin scale (mRS) 0-1)
- Follow-up
- 90 days
Methodological detailsdesign/protocol paper, investigator-initiated, emergency medical services (EMS) randomisation at the scene, 20-25 European and US sites
- Design/protocol paper
- Investigator-initiated
- EMS randomisation at the scene
- 20-25 European and US sites
No results yet. This paper sets out the design of a trial; its results are to come.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The design of the PRINCESS 2 trial: A randomized trial to study the impact of ultrafast hypothermia on complete neurologic recovery after out-of-hospital cardiac arrest with initial shockable rhythm. Am Heart J. Published 28 February 2024. doi:10.
Summarised from the published abstract; every number is checked against it