Aortic & peripheral vascular disease
Design and rationale of the clinical trial to obtain the highest efficacy of dual antiplatelet therapy after carotid artery stenting in high bleeding risk patients (CHET): A multicenter, randomized, open-label, superiority trial
Study context
- Population
- Patients with high bleeding risk (HBR) undergoing carotid artery stenting (CAS)final target (778 per group), allowing 2% dropout, 328 participants enrolled as of February 5, 2026
- Participants
- 1,556 patients
- Planned comparison
- Abbreviated dual antiplatelet therapy (DAPT) followed by SAPT compared to prolonged DAPT
- SAPTn = 778
- DAPTn = 778
- Primary endpoint
- Clinically significant bleeding (BARC 2, 3, or 5) (primary safety endpoint)
- Follow-up
- From day 30 to 12 months post-CAS
Methodological detailsdesign and rationale, enrichment period of 30 days DAPT before 1:1 randomization
- Design and rationale
- Enrichment period of 30 days DAPT before 1:1 randomization
No results yet. This paper sets out the design of a trial; its results are to come.
Further findings
Enrollment status · As of February 5, 2026
- Participants enrolled
- 328
- Enrollment began July 15, 2024; expected completion November 2029, follow-up by December 2030
Original publication
Design and rationale of the clinical trial to obtain the highest efficacy of dual antiplatelet therapy after carotid artery stenting in high bleeding risk patients (CHET): A multicenter, randomized, open-label, superiority trial. Am Heart J. Published 7 March 2026. doi:10.
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