Aortic & peripheral vascular disease
Aortic and Iliac Calcifications as Predictors of Aortic Dissection, Aneurysm Rupture, and Peripheral Vascular Disease: A Prospective Cohort Study from the DANCAVAS Trials
Authors' conclusion
Severe aortic and iliac calcification was associated with significantly higher risk of aortic events and MALEs
Study context
- Population
- DANCAVAS participants with full thoracoabdominal aortic CT and recorded aortic and iliac calcification94% men
- Participants
- 13,065 participants
- Exposure
- Highest vs lower aortic and iliac calcification scores
- Outcome
- Aortic events (aortic dissection or aneurysm rupture) and MALEs (peripheral revascularization and lower limb amputation)
- Follow-up
- Mean 8 years
Methodological detailspopulation-based, competing risk regression
- Population-based
- Competing risk regression
Main finding
As reported in the abstract
Subdistribution hazard ratio (95% CI)
Ascending aorta, fourth groupaortic events
3.06(1.15–8.16)
Abdominal aorta, fourth quartileaortic events
7.61(1.44–40.22)
Ascending aorta, fourth groupMALEs
2.20(1.56–3.10)
Aortic arch, fourth quartileMALEs
6.49(3.10–13.56)
Descending aorta, fourth quartileMALEs
2.43(1.45–4.08)
Abdominal aorta, fourth quartileMALEs
7.89(2.95–21.15)
Iliac arteries, fourth quartileMALEs
13.52(4.32–42.24)
- Aortic events
- 42
- Major adverse limb events (MALEs)
- 311
Observational data: associations, not effects.
Original publication
Aortic and Iliac Calcifications as Predictors of Aortic Dissection, Aneurysm Rupture, and Peripheral Vascular Disease: A Prospective Cohort Study from the DANCAVAS Trials. Circulation. Published 2 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →