Design and rationale of the HARTc 2.0 trial: A multicenter randomized controlled study on the impact of point-of-care high-sensitivity cardiac troponin-I testing in prehospital acute coronary syndrome triage on diagnosis and cost-effectiveness
Study context
- Population
- Patients with suspected acute coronary syndrome (ACS) in prehospital triage
- Planned comparison
- Modified HEART score vs Standard care
- Primary endpoint
- Impact of prehospital risk stratification (low, intermediate or high risk for ACS) on clinical decision-making, time-to-diagnosis and cost-effectiveness
Methodological details4 prospective phases, Phase 0: technical operability of Siemens Atellica VTLi point-of-care (POC) high-sensitivity cardiac troponin-I (hs-cTnI) device; Phase 1: preanalytical and analytical performance; Phase 2: clinical comparability of modified vs standard HEART score; Phase 3: multicentre RCT
- 4 prospective phases
- Phase 0: technical operability of Siemens Atellica VTLi POC hs-cTnI device; Phase 1: preanalytical and analytical performance; Phase 2: clinical comparability of modified vs standard HEART score; Phase 3: multicentre RCT
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Design and rationale of the HARTc 2.0 trial: A multicenter randomized controlled study on the impact of point-of-care high-sensitivity cardiac troponin-I testing in prehospital acute coronary syndrome triage on diagnosis and cost-effectiveness. Am Heart J. Published 16 July 2025. doi:10.
Summarised from the published abstract; every number is checked against it